Objective, Quantitative, Data-Driven Assessment of Chemical Probes
نویسندگان
چکیده
Chemical probes are essential tools for understanding biological systems and for target validation, yet selecting probes for biomedical research is rarely based on objective assessment of all potential compounds. Here, we describe the Probe Miner: Chemical Probes Objective Assessment resource, capitalizing on the plethora of public medicinal chemistry data to empower quantitative, objective, data-driven evaluation of chemical probes. We assess >1.8 million compounds for their suitability as chemical tools against 2,220 human targets and dissect the biases and limitations encountered. Probe Miner represents a valuable resource to aid the identification of potential chemical probes, particularly when used alongside expert curation.
منابع مشابه
Dispersive liquid-liquid microextraction using silver nanoparticles as electrostatic probes for preconcentartion and quantitative analysis of terazosin
An efficient dispersive liquid-liquid microextraction using tetraalkylammonium bromide coated silver nanoparticles (DLLME-AgNPs) prepared in chloroform has been successfully applied as electrostatic affinity probes to the microextraction and preconcentration of terazosin prior to spectrofluorimetry analysis. This technique is based on a ternary system of solvents, where appropriate amount of mi...
متن کاملبررسی آثار اقتصادی و اجتماعی محدودیت عرضه فرآوردههای نفتی با استفاده از الگوی مختلط ماتریس حسابداری اجتماعی
Today the quantitative assessment of economic and social impacts of petroleum products supply constraints is one of the main policy issues in Iran. This issue arises from the fact that importing gasoline, gasoil and liquefied petroleum gas (LPG) is restricted by international sanctions. In this paper, we showed that a demand driven Social Accounting Matrix (SAM) is not a suitable tool for ans...
متن کاملQuantitative Safety and Health Assessment Based on Fuzzy Inference and AHP at Preliminary Design Stage
Quantitative assessment is the most important means to identify hazard potential and manage risk for an industrial process. The implement of quantitative assessment in the early stage will help to develop inherently safer process, eliminating the hazard and reduce the possibility of accidental chain events and the magnitude of consequences. In this paper, after reviewing the presently available...
متن کاملThe Role of Quantitative Risk Assessment in Improving Hazardous Installations Siting: A Case Study
Safety distance has already been a main measurement for the hazard control of chemical installations interpreted to mean providing space between the hazardous installation and different types of targets. But, the problem is how to determine the enough space. This study considers the application of quantitative risk assessment to evaluating a compressed natural gas station site and to identi...
متن کاملDispersive liquid-liquid microextraction using silver nanoparticles as electrostatic probes for preconcentartion and quantitative analysis of terazosin
An efficient dispersive liquid-liquid microextraction using tetraalkylammonium bromide coated silver nanoparticles (DLLME-AgNPs) prepared in chloroform has been successfully applied as electrostatic affinity probes to the microextraction and preconcentration of terazosin prior to spectrofluorimetry analysis. This technique is based on a ternary system of solvents, where appropriate amount of mi...
متن کامل